When introducing genes into yeast to make it produce drugs and other useful substances, it is also necessary to reliably switch the production on or off. A Kobe University team found three gene regulation design principles that provide a flexible guideline for the effective control of microbiological production.
It’s said that DNA is the blueprint of life, telling our cells what to produce. But DNA also contains the switches telling those cells when to produce something and how much of it. Therefore, when introducing new genes into cells to produce useful chemicals such as drugs or raw materials for chemical production, it is also necessary to include a genetic switch, a piece of DNA called a “promoter,” that tells the cells to start production as needed. Kobe University bioengineer TOMINAGA Masahiro says: “The problem is that these promoters cannot be used in a plug-and-play manner unless researchers deeply understand how they interact with other genetic elements. Indeed, there are not so many…
